It is evident that biochemical control is not strictly hierarchical
and that intermediary metabolism can contribute to control of
regulatory pathways. Metabolic studies are therefore increasingly
important in gene function analyses, and an increased interest in
metabolites as biomarkers for disease progression or response to
therapeutic intervention is also evident in the pharmaceutical
industry. This book offers guidelines to currently available
technology and bioinformatics and database strategies now being
developed. Evidence is presented that metabolic profiling is a
valuable addition to genomics and proteomics strategies devoted to
drug discovery and development, and that metabolic profiling offers
numerous advantages.
General
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