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Books > Medicine > Clinical & internal medicine > Medical diagnosis
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Virtual Screening: An Alternative or Complement to High Throughput Screening? - Proceedings of the Workshop 'New Approaches in Drug Design and Discovery', special topic 'Virtual Screening', Schloss Rauischholzhausen, Germany, March 15-18, 1999 (Hardcover, Reprinted from perspectives in drug discovery and design, 20, 2001)
Loot Price: R4,395
Discovery Miles 43 950
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Virtual Screening: An Alternative or Complement to High Throughput Screening? - Proceedings of the Workshop 'New Approaches in Drug Design and Discovery', special topic 'Virtual Screening', Schloss Rauischholzhausen, Germany, March 15-18, 1999 (Hardcover, Reprinted from perspectives in drug discovery and design, 20, 2001)
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In the next couple of years the human genome will be fully
sequenced. This will provide us with the sequence and overall
function of all human genes as well as the complete genome for many
micro-organisms. Subsequently it is hoped, by means of powerful
bioinformatic tools, to determine the gene variants that contribute
to various multifactorial diseases and genes that exist in certain
infectious agents but not humans. As a consequence, this will allow
us to define the most appropriate levels for drug intervention. It
can be expected that the number of potential drug targets will
increase, possibly by a factor of 10 or more. Nevertheless,
sequencing the human genome or, for that matter, the genome of
other species will only be the starting point for the understanding
of their biological function. Structural genomics is a likely
follow-up, combined with new techniques to validate the therapeutic
relevance of such newly discovered targets. Accordingly, it can be
expected that in the near future we will witness a substantial
increase in novel putative targets for drugs. To address these new
targets effectively, we require new approaches and innovative
tools. At present, two alternative, yet complementary, techniques
are employed: experimental high-throughput screening (HTS) of large
compound libraries, increasingly provided by combinatorial
chemistry, and computational methods for virtual screening and de
novo design. As kind of status report on the maturity of virtual
screening as a technique in drug design, the first workshop on new
approaches in drug design and discovery was held in March 1999, at
Schloss Rauischholzhausen, near Marburg in Germany. More than 80
scientists gathered and discussed their experience with the
different techniques. The speakers were invited to summarize their
contributions together with their impressions on the present
applicability of their approach. Several of the speakers followed
this request which is summarized in this publication."
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