It is now 10 years since the first AIDS cases were reported in the
USA. In that relatively short period of time, study of the disease
has moved from the level of early clinical description to
exhaustive and extensive laboratory characterization of the human
immunodeficiency virus (HIV), the immune responses directed towards
it and reasons for their failure. This volume provides
contributions from clinical and basic scientists who are actively
involved in research in a number of areas of current interest and
controversy. Further progress in the clinical management of the
HIV-infected patient will undoubtedly build on the basic knowledge
about HIV and its modes of pathogenesis. The intimate relationship
between HIV and the human immune system provides observations and
questions that are relevant to viral immunopathogenesis in general.
In the first chapter the clinical features of HIV immunodeficiency
are re viewed, and aspects of its changing face are discussed. Dr
Tersmette then presents evidence for changing viral characteristics
at different stages of the disease. This view of close competition
for ascendancy between HIV and the host immune response raises
questions about current approaches to therapy."
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