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Books > Science & Mathematics > Biology, life sciences > Developmental biology
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Pharmacology of the WNT Signaling System (Paperback, 1st ed. 2021)
Loot Price: R4,615
Discovery Miles 46 150
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Pharmacology of the WNT Signaling System (Paperback, 1st ed. 2021)
Series: Handbook of Experimental Pharmacology, 269
Expected to ship within 10 - 15 working days
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This book reflects the state of the art of our understanding of the
WNT signaling system, which comprises a network of signaling
pathways initiated by the secreted WNT lipoglycoproteins, which are
crucial for embryonal development, stem cell regulation, tissue
homeostasis and repair. Dysfunction of this evolutionarily
conserved signaling system leads to many diseases including
developmental disorders, diverse forms of cancer, fibrosis,
neurodegenerative disease and many more. The WNT signaling system
is built upon 19 mammalian, secreted WNT lipoglycoproteins that
interact with a plethora of distinct receptors, such as the G
protein-coupled receptors called Frizzleds (FZD1-10), LDL
receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1,
2, RYK and PTK7). In addition, WNT pathways are tightly regulated
by many secreted and cell-intrinsic negative regulators, such as
soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs),
WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the
basic mechanism in terms of receptor-ligand interaction, receptor
selectivity, signal initiation and desensitization remain poorly
understood, even though substantial advances have been made the
recent years. Due to the involvement of the WNT signaling system in
human disease, it appears obvious to target diverse branches
pharmacologically and therapeutically. However, given the
complexity of the system and its importance for stem cell
regulation and tissue maintenance, therapy comes with obvious risks
for severe side effects. The field is addressing the challenge to
identify suitable targets and selective compounds for therapy
allowing disease-selective therapeutic effects and balancing
unwanted side effects. This book summarizes the current
understanding of the basic and applied pharmacology in the WNT
signaling system and bridges disciplines such as pharmacology,
physiology, neurosciences, oncology and drug development.
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