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Books > Medicine > Clinical & internal medicine > Paediatric medicine
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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis (Paperback, 2012 ed.)
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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis (Paperback, 2012 ed.)
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The human foetus is separated from the maternal blood by the
syncytiotrophoblast induced by endogeneous human retrovirus-encoded
proteins. This barrier is a highly developed one, which suppors
apical-basolateral transport of maternal idiotype and anti-idiotype
IgG, IgG-virus complexes. The selective maternal-fetal transport of
epitope- and paratope-bearing entities can influence the
developping fetal immune system during pregnancy. The bidirectional
maternal-fetal transfer of cells are of even more importance during
pregnancy. Maternal cells with latent viruses transport viruses
without impairment of fetal development. Cells with premaligant and
malignant genetic transformation are also transported to the fetus.
Fetal and neonatal tumours are initiated by such cells in spite of
the antitumour potential of fetal organism. On the contary, the
fetal cells repair maternal tissue injouries and survive in the
organisms of the recipients for decades. These possess new
consequences for the neonatal immunity and organ transplatation
surgery.
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