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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Endothelial Mechanisms of Vasomotor Control - With special Reference to the Coronary Circulation (Paperback, Softcover reprint of the original 1st ed. 1991)
Loot Price: R2,872
Discovery Miles 28 720
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Endothelial Mechanisms of Vasomotor Control - With special Reference to the Coronary Circulation (Paperback, Softcover reprint of the original 1st ed. 1991)
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In recent years, we have witnessed a rapid expansion of our
knowledge regarding the role of the endothelium in the control of
vascular tone (and organ perfusion) in health and disease.
Physiology, pharmacology, and molecular biology have uncovered a
wealth of information on structure and function of this heretofore
largely neglected "organ". Clinical medicine is now called upon to
define the clinical significance of these observa tions that imply
the mechanisms of blood coagulation, e.g., the interaction of throm
bocytes with the endothelium, vasomotor control, and specifically,
the regulation of smooth muscle tone with consequences for vascular
resistance and conductance and organ blood flow. Finally,
metabolism of lipids with the everlasting problem of athero
sclerosis is an important aspect. In a second step, implications
regarding the improvement of current therapeutic con cepts, as well
as the development of new modalities of pharmacotherapy will have
to be discussed. The topic addressed by the 1990 Gargellen
Conference: Endothelial Mechanisms of Vasomotor Control, clearly is
of interest for both basic scientists and clinicians. It has been
the aim of the organizers, the Society for Cooperation in Medical
Science (SCMS) with this and the previous symposia to foster and
support both basic science and clinical research. Research in
medicine today shows two major directions of development: on the
one hand, increasing involvement of the basic sciences and their
methodology. On the other hand, statistical validation of concepts
and therapeutic strategies in large scale population-and
multicenter-studies.
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