Inhibitors of Nucleic Acid Synthesis - Biophysical and Biochemical Aspects (Paperback, Softcover reprint of the original 1st ed. 1974)

During the last decade physical and chemical methods have improved rapidly - a fact which allowed the mode of action of antibiotics to be studied - and many biochemically-oriented scientists have devoted their research to the following questions: 1. What is the metabolic pathway that is inhibited selectively, and what are the target molecules within a sensitive cell? 2. What are the relationships between the chemical structure of an antibiotic and the physicochemical properties of the sensitive mole cule(s)? 3. Why and how far is the action selective? 4. Is it possible to correlate the interaction with the target mole cule(s) with the particular biological activities observed? This monograph deals with those antibiotics which interfere with the biosynthesis of nucleic acids. The idea was to provide an insight into how to investigate the preceding questions experimentally and to solve as yet unresolved problems rather than to give a review of the current state of knowledge. Although the biochemistry of nucleic acid synthesis is known in general, the precise molecular mechanisms by which deoxyribonucleic acid is replicated or transcribed has still to be clarified. For this reason it is not yet possible to describe the molecular mechanisms by which the inhibitors of nucleic acid and protein synthesis exhibit their effects. The fact that the inhibitors of nucleic acid and protein synthesis themselves served as useful tools to obtain an insight into the mechanisms of replication, transcription and translation was one of the most exciting discoveries in this field."

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik, 18
Release date:	December 2011
First published:	1974
Authors:	H. Kersten • W Kersten
Dimensions:	244 x 170 x 10mm (L x W x T)
Format:	Paperback
Pages:	186
Edition:	Softcover reprint of the original 1st ed. 1974
ISBN-13:	978-3-642-80857-9
Categories:	Books > Professional & Technical > Biochemical engineering > General Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-642-80857-3
Barcode:	9783642808579

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