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Functions of Glutathione in Liver and Kidney (Paperback, Softcover reprint of the original 1st ed. 1978)
Loot Price: R2,948
Discovery Miles 29 480
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Functions of Glutathione in Liver and Kidney (Paperback, Softcover reprint of the original 1st ed. 1978)
Series: Proceedings in Life Sciences
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The serene phrase, Lest I forget thee, glutathione ..., coined by
the Kosowers (1) to describe the state in the 1960's, must be
replaced now by something like "Inevitable GSH" in order to
characterize the current situation. The surge in interest on the
ubiquitous tripeptide has been ama- zing, with publications on GSH
running at rates as high as one per day, so that it seemed
appropriate to convene international experts for a discussion of
recent develop- ments this year. Unlike the two previous meetings
in this decade held in Tlibingen in 1973 (2) and in santa Ynez in
1975 (3), the scope was restricted to Functions of Gluta- thione in
Liver and Kidney. Only in this way did an in-depth discussion of
the current state of knowledge in a limit- ed topic appear
possible. The last couple of years have seen a fascinating pro-
ductivity in the fields of (a) Regulation of the Glutathione Level
in the Liver, (b) Role of y-Glutamyltransferase in Gluta- thione
Turnover with emphasis on the renal enzyme, and a critical
appraisal of the y-Glutamyl Cycle, (c) Hyd:roperox- ide and
Disulfide Metaholism, enriched by the discovery of the
nonseleniurn-dependent glutathione peroxidase activ- ity and its
relation to the glutathione-S-transferases, and the participation
of the 2GSH/GSSG system in redox transitions in intact organ, cells
and isolated mito- chondria, and (d) a multitude of Pharmacological
and Toxi- cological Aspects related to glutathione, mainly centered
on the events leading to liver damage and the protective
General
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