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Tumor Prevention and Genetics (Paperback, Softcover reprint of the original 1st ed. 2003)
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Tumor Prevention and Genetics (Paperback, Softcover reprint of the original 1st ed. 2003)
Series: Recent Results in Cancer Research, 163
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Hans-Jorg Senn H.-J. Senn (~) Center for Tumor Detection and
Prevention, Rorschacherstr. 150, CH-9006 St. Gallen, Switzerland
Clinical oncology has centered mainly on developing new strategies
and a multitude of new drugs for fighting relapsing and progressive
cancer during the last two decades. Furthermore, it has done this
with respectable success in quite a number of neoplastic diseases
such as acute leukemias and sarcomas in pediatric patients and
certain types of aggressive lymphomas, as well as se lected solid
tumors such as testicular cancer and choriocarcinoma in adult age.
Curatively intended adjuvant chemo-and endocrine-therapies of
several "main killers" among prevalent cancer types, especially
breast and colon can cer, have also become successful and
health-politically meaningful therapeutic targets [1, 2]. However,
the net gain in "cure" of these (mostly pharmacologic) therapeu tic
approaches has to be realistically judged as having a moderate
impact on the cancer problem as a whole, and the mortality rate of
the most frequent tu mor types, which are prevalent in adult life,
has with very few exceptions not been substantially decreased over
the past two to three decades. Increasingly, health politicians,
epidemiologists, and medical journal editors are asking for
alternative strategies of lowering cancer incidence and increasing
survival, ventilating new and hitherto mostly neglected areas of
research such as pri mary and secondary cancer prevention.
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