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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cell Death - Mechanism and Disease (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R5,308
Discovery Miles 53 080
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Cell Death - Mechanism and Disease (Paperback, Softcover reprint of the original 1st ed. 2014)
Expected to ship within 10 - 15 working days
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Beginning from centuries of anecdotal descriptions of cell death,
such as those on the development of the midwife toad in 1842 by
Carl Vogt, to modern-day investigations of cell death as a
biological discipline, it has become accepted that cell death in
multicellular organisms is a normal part of life. This book
provides a comprehensive view of cell death, from its mechanisms of
initiation and execution, to its implication in human disease and
therapy. Physiological cell death plays critical roles in almost
all aspects of biology, and the book details its roles in
lymphocyte homeostasis, neuronal function, metabolism, and the DNA
damage response. When physiological cell death goes awry, diseases
can arise, and cancer is presented as a central paradigm for the
consequences of derangements in the interplay between cell survival
and cell death. At the same time, the potential promise of targeted
therapies aimed at interdicting cell death machineries are also
discussed extensively. The molecular mechanisms that underlie
apoptotic cell death are illustrated from the perspectives of both
the intrinsic, mitochondrial apoptotic pathway and the extrinsic,
death receptor pathway. Key players in these pathways, such as the
Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death
receptor adapter proteins, and inhibitor of apoptosis proteins, are
presented from both functional and structural angles. Until only a
few years ago, programmed cell death has been considered
essentially synonymous with apoptosis. However, we now know that
programmed cell death can also take other forms such as necrosis or
necroptosis, and to this end, the mechanisms that underlie
programmed necrosis in development and host defense are
illustrated. The past twenty plus years have seen an incredible
growth of research in cell death, with one breakthrough after
another, and the legacy still goes on with constant new surprises
and findings. Long live cell death!
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