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Mass Spectrometry for the Clinical Laboratory (Hardcover)
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Mass Spectrometry for the Clinical Laboratory (Hardcover)
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Mass Spectrometry for the Clinical Laboratory is an accessible
guide to mass spectrometry and the development, validation, and
implementation of the most common assays seen in clinical labs. It
provides readers with practical examples for assay development, and
experimental design for validation to meet CLIA requirements,
appropriate interference testing, measuring, validation of ion
suppression/matrix effects, and quality control. These tools offer
guidance on what type of instrumentation is optimal for each assay,
what options are available, and the pros and cons of each. Readers
will find a full set of tools that are either directly related to
the assay they want to adopt or for an analogous assay they could
use as an example. Written by expert users of the most common
assays found in a clinical laboratory (clinical chemists,
toxicologists, and clinical pathologists practicing mass
spectrometry), the book lays out how experts in the field have
chosen their mass spectrometers, purchased, installed, validated,
and brought them on line for routine testing. The early chapters of
the book covers what the practitioners have learned from years of
experience, the challenges they have faced, and their
recommendations on how to build and validate assays to avoid
problems. These chapters also include recommendations for
maintaining continuity of quality in testing. The later parts of
the book focuses on specific types of assays (therapeutic drugs,
Vitamin D, hormones, etc.). Each chapter in this section has been
written by an expert practitioner of an assay that is currently
running in his or her clinical lab.
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