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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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SUMO Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2009)
Loot Price: R2,432
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SUMO Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2009)
Series: Methods in Molecular Biology, 497
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Post-translational protein modifications by members of the
ubiquitin family are widely recognized as important regulatory
control systems for a variety of biological pathways. Their
influence on eukaryotic cellular metabolism is comparable to that
of other modifi- tions such as phosphorylation, acetylation and
methylation. The small ubiquitin-related modifier SUMO uses a
conjugation and de-conjugation system closely related to that of
ubiquitin itself; yet, the functions of the SUMO system are highly
diverse and largely independent of the ubiquitin system. SUMO
modification controls the activity of tr- scription factors and can
influence protein stability, but it also contributes to nucleo-cy-
plasmic transport, chromosome segregation and DNA damage repair. As
a consequence, the SUMO system pervades virtually all areas of
basic molecular and cell biology, and scientists from different
backgrounds, including medical researchers, are likely to enco- ter
SUMO in the course of their studies. This volume, SUMO Protocols,
therefore aims at presenting a collection of methods relevant to
SUMO research in order to make these tools available to
biochemists, molecular and cell biologists as well as
research-oriented clinicians not yet familiar with the system. In
contrast to the ubiquitin system, which has been the subject of
several reviews and methods collections, no practical compendium
entirely devoted to SUMO has been p- lished.
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