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Horizons in Cancer Research - Volume 60 (Hardcover)
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Horizons in Cancer Research - Volume 60 (Hardcover)
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This book presents original results on the leading edge of cancer
research. Lipomas are extremely common benign lesions, representing
the most common softtissue tumor, with a wide spectrum of clinical
presentations and imaging appearances. Several subtypes are
described, ranging from lesions entirely composed of mature adipose
tissue to tumors intimately associated with nonadipose tissue, to
those composed of brown fat. Chapter one begins with an overview of
the available evidence about the classification, clinical
manifestations, diagnostic tests and treatment options of lipomas.
The following three chapters examine parosteal lipomas and giant
lipomas. Chapter five studies the first literary description of
cavernous angiolipoma of the subcutis in a 75-year-old man,
delivering a new lipomatous entity. Chapter six focuses on immune
plasticity and susceptibility to cancer from fanconi anemia, which
is characterised as a genetic disorder of genomic instability, with
main clinical symptoms involving congenital abnormalities,
infertility, bone marrow failure and a predisposition to the
development of several types of cancer, especially acute
myelogenous leukemia (AML) and head and neck carcinomas. Chapter
seven discusses radiotherapy for patients with fanconi anemia.
Chapters eight and nine examine the effects of ursolic acid (UA)
and flavonol-enriched extract (FL) on the cell cycle behaviour of
DU145 human prostate cancer cells in vitro. Chapter ten describes
the most current advances made in characterising the role of PLA2
in tumor development and progression, as well as highlight some of
our most recent studies involving iPLA2 and cancer. The remaining
chapters discuss the preclinical rationale for targeting human EGFR
and recent clinical reports of targeted agents in esophageal
cancer; study the pharmaceutical properties and drug likeness of
anticancer drugs administered for the clinical treatment of lung
cancer; and covers the epidemiology, different etiology and
pathogenesis of hepatocellular carcinoma.
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