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Nonhuman Primate Models in Preclinical Research. Volume 2 - Disease Models (Hardcover)
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Nonhuman Primate Models in Preclinical Research. Volume 2 - Disease Models (Hardcover)
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Despite many encouraging developments in the field of animal-free
technologies, well-defined animal models are still needed to study
fundamental properties of human diseases and to develop new
prophylactic and therapeutic treatments against human diseases.
Non-human primates (NHP) make up only a small, but important, part
of the total number of animals used in biomedical and preclinical
research. Due to their close phylogenetic relationship and the
shared susceptibility to many human diseases, NHP can provide
important research models to study these diseases and, as such,
play a critical role in the advancement of various areas in the
medical field. Studies in NHP have contributed to our understanding
of various diseases and fundamental biological phenomena and they
continue to be important in the development of new therapies,
treatments, drugs and vaccines. Moreover, NHP models also
contribute to our general knowledge of the processes that underlie
non-disease and disease conditions. Important areas where NHP can
provide important information include (emerging) infectious
diseases, organ transplantation, neurological and aging-related
disorders. Although not covered in this book due to time
constraints, the need for, and benefits of, NHP models has been
demonstrated most recently in the SARS-CoV-2 pandemic. The present
book is the second of two volumes and covers important disease
areas where NHP are used as model species. This volume includes
different chapters on NHP models in infectious diseases, aging,
neurodegenerative disorders, organ transplantation and cancer.
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