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Improving the Utility and Translation of Animal Models for Nervous System Disorders - Workshop Summary (Paperback)
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Improving the Utility and Translation of Animal Models for Nervous System Disorders - Workshop Summary (Paperback)
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Nervous system diseases and disorders are highly prevalent and
substantially contribute to the overall disease burden. Despite
significant information provided by the use of animal models in the
understanding of the biology of nervous system disorders and the
development of therapeutics; limitations have also been identified.
Treatment options that are high in efficacy and low in side effects
are still lacking for many diseases and, in some cases are
nonexistent. A particular problem in drug development is the high
rate of attrition in Phase II and III clinical trials. Why do many
therapeutics show promise in preclinical animal models but then
fail to elicit predicted effects when tested in humans? On March 28
and 29, 2012, the Institute of Medicine Forum on Neuroscience and
Nervous System Disorders convened the workshop "Improving
Translation of Animal Models for Nervous System Disorders" to
discuss potential opportunities for maximizing the translation of
new therapies from animal models to clinical practice. The primary
focus of the workshop was to examine mechanisms for increasing the
efficiency of translational neuroscience research through
discussions about how and when to use animal models most
effectively and then best approaches for the interpretation of the
data collected. Specifically, the workshop objectives were to:
discuss key issues that contribute to poor translation of animal
models in nervous system disorders, examine case studies that
highlight successes and failures in the development and application
of animal models, consider strategies to increase the scientific
rigor of preclinical efficacy testing, explore the benefits and
challenges to developing standardized animal and behavioral models.
Improving the Utility and Translation of Animal Models for Nervous
System Disorders: Workshop Summary also identifies methods to
facilitate development of corresponding animal and clinical
endpoints, indentifies methods that would maximize bidirectional
translation between basic and clinical research and determines the
next steps that will be critical for improvement of the development
and testing of animal models of disorders of the nervous system.
Table of Contents Front Matter 1 Introduction and Overview 2
Evaluation of Current Animal Models 3 Translation from Animal
Models to the Clinic: Case Examples from Neuroscience Research 4
Perspectives on Standardization 5 Perspectives on Corresponding
Animal and Clinical Endpoints 6 Addressing the Translational
Disconnect 7 Summary of Workshop Topics Appendix A: References
Appendix B: Workshop Agenda Appendix C: Registered Attendees
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