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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Wood Dust and Formaldehyde - IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (Paperback)
Loot Price: R1,316
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Wood Dust and Formaldehyde - IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (Paperback)
Series: IARC Monographs, v. 62
Expected to ship within 10 - 15 working days
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Evaluates the carcinogenic risk to humans posed by occupational
exposures to wood dust and formaldehyde. A number of occupational
situations that involve exposure to wood dust also entail exposure
to formaldehyde, as in plywood and particle board manufacture,
during furniture and cabinet-making, and during parquet floor
sanding and varnishing. The carcinogenic risks of wood dust are
evaluated in the first monograph. The highest occupational
exposures were noted to occur in wood furniture and cabinet
manufacture, especially during machine sanding and similar
operations, in the finishing departments of plywood and
particle-board mills, and in the workroom air of sawmills and
planer mills near chippers, saws, and planers. Citing findings from
several recent well-designed case-control studies, the monograph
concludes that occupational exposure to wood dust is causally
related to adenocarcinoma of the nasal cavities and paranasal
sinuses. The evaluation further concluded that the excess risk of
cancer is attributable to wood dust per se, rather than to other
exposures in the workplace. Wood dust was classified as
carcinogenic to humans. Cancer risk associated with occupational
exposure to formaldehyde is assessed in the second monograph. The
assessment draws on findings from several cohort and case-control
investigations of the relationship between exposure to formaldehyde
and cancer of the oral cavity, pharynx, and respiratory tract.
Citing inconsistencies in the reported results, the monograph
concludes that these epidemiological studies can do no more than
suggest a causal role of occupational exposure to formaldehyde in
carcinoma of the nasal cavities and paranasal sinuses. The review
found no evidence of excess risk for oropharyngeal, laryngeal or
lung cancer among exposed workers. Several studies in which
formaldehyde was administered to rats by inhalation showed evidence
of carcinogenicity. Similar studies in hamsters showed no evidence
of carcinogenicity, and studies in mice either showed no effect or
were inadequate for evaluation. In rats administered formaldehyde
in drinking-water, increased incidences were seen of forestomach
papillomas in one study and of leukaemias and gastrointestinal
tract tumours in another; two other studies gave negative results.
Formaldehyde was classified as probably carcinogenic to humans.
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