Modelling the Short QT Syndrome Gene Mutations - And Their Role in Cardiac Arrhythmogenesis (Paperback, Softcover reprint of the original 1st ed. 2014)

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases. The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as "outstanding."

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	September 2016
First published:	2014
Authors:	Ismail Adeniran
Dimensions:	235 x 155 x 13mm (L x W x T)
Format:	Paperback
Pages:	217
Edition:	Softcover reprint of the original 1st ed. 2014
ISBN-13:	978-3-319-36151-2
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Science & Mathematics > Mathematics > Applied mathematics > General Books > Science & Mathematics > Physics > Thermodynamics & statistical physics > Statistical physics Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Promotions
LSN:	3-319-36151-1
Barcode:	9783319361512

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