Computational Biology of Transcription Factor Binding (Paperback, Softcover reprint of the original 1st ed. 2010)

Transcriptional regulation controls the basic processes of life. Its complex, dynamic, and hierarchical networks control the momentary availability of messenger RNAs for protein synthesis. Transcriptional regulation is key to cell division, development, tissue differen- ation, and cancer as discussed in Chapters 1 and 2. We have witnessed rapid, major developments at the intersection of computational biology, experimental technology, and statistics. A decade ago, researches were struggling with notoriously challenging predictions of isolated binding sites from low-throughput experiments. Now we can accurately predict cis-regulatory modules, conserved cl- ters of binding sites (Chapters 13 and 15), partly based on high-throughput ch- matin immunoprecipitation experiments in which tens of millions of DNA segments are sequenced by massively parallel, next-generation sequencers (ChIP-seq, Chapters 9, 10, and 11). These spectacular developments have allowed for the genome-wide mappings of tens of thousands of transcription factor binding sites in yeast, bacteria, mammals, insects, worms, and plants. Please also note the no less spectacular failures in many laboratories around the world.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 674
Release date:	August 2016
First published:	2010
Editors:	Istvan Ladunga
Dimensions:	254 x 178mm (L x W)
Format:	Paperback
Pages:	454
Edition:	Softcover reprint of the original 1st ed. 2010
ISBN-13:	978-1-4939-6166-5
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
LSN:	1-4939-6166-7
Barcode:	9781493961665

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