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Books > Science & Mathematics > Biology, life sciences > Developmental biology
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Developmental Patterning of the Vertebrate Limb (Paperback, Softcover reprint of the original 1st ed. 1991)
Loot Price: R1,630
Discovery Miles 16 300
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Developmental Patterning of the Vertebrate Limb (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: NATO Science Series A:, 205
Expected to ship within 10 - 15 working days
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Following pioneering work by Harrison on amphibian limbs in the
1920s and by Saunders (1948) on the apical ridge in chick limbs,
limb development became a classical model system for investigating
such fundamental developmental issues as tissue interactions and
induction, and the control of pattern formation. Earlier
international conferences, at Grenoble 1972, Glasgow 1976,and
Storrs, Connecticut 1982, reflected the interests and technology of
their time. Grenoble was concerned with ectoderm-mesenchyme
interaction, but by the time of the Glasgow meeting, the zone of
polarizing activity (ZPA) and its role in control of patterning was
the dominant theme. Storrs produced the first intimations that the
ZPA could be mimicked by retinoic acid (RA), but the diversity of
extracellular masrix ~olecules,particularly in skeletogenesis,was
the main focus of attention. By 1990, the paradigms had again
shifted. Originally, the planners of the ARW saw retinoic acid (as
a possible morphogen controlling skeletal patterning), the variety
of extracellular matrix components and their roles, and the
developmental basis of limb evolution as the leading contemporary
topics. However, as planning proceeded, it was clear that the new
results emerging from the use of homeobox gene probes (first
developed to investigate the genetic control of patterning of
Drosophila embryos) to analyse the localised expression of
"patterning genes" in limb buds would also be an important theme.
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