Lipids are the most abundant organic compounds found in the
brain, accounting for up to 50% of its dry weight. The brain
lipidome includes several thousands of distinct biochemical
structures whose expression may greatly vary according to age,
gender, brain region, cell type, as well as subcellular
localization. In synaptic membranes, brain lipids specifically
interact with neurotransmitter receptors and control their
activity. Moreover, brain lipids play a key role in the generation
and neurotoxicity of amyloidogenic proteins involved in the
pathophysiology of neurological diseases. The aim of this book is
to provide for the first time a comprehensive overview of brain
lipid structures, and to explain the roles of these lipids in
synaptic function, and in neurodegenerative diseases, including
Alzheimer s, Creutzfeldt-Jakob s and Parkinson s. To conclude the
book, the authors present new ideas that can drive innovative
therapeutic strategies based on the knowledge of the role of lipids
in brain disorders.
*Written to provide a "hands-on" approach for readers
*Biochemical structures explained with molecular models, and
molecular mechanisms explained with simple drawings
*Step-by-step guide to memorize and draw lipid structures
*Each chapter features a content summary, up-to-date references for
additional study, and a key experiment with an explanation of the
technique"
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