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Chromatin Regulation of Early Embryonic Lineage Specification (Paperback, 1st ed. 2018)
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Chromatin Regulation of Early Embryonic Lineage Specification (Paperback, 1st ed. 2018)
Series: Advances in Anatomy, Embryology and Cell Biology, 229
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Five leaders in the field of mammalian preimplantation embryo
development provide their own perspectives on key molecular and
cellular processes that mediate lineage formation during the first
week of life. The first cell-fate decision involves the formation
of the pluripotent inner cell mass (ICM) and extraembryonic
trophectoderm (TE). The second cell-fate choice encompasses the
transformation of ICM into extraembryonic primitive endoderm (PE)
and pluripotent epiblast. The processes, which occur during the
period of preimplantation development, serve as the foundation for
subsequent developmental events such as implantation, placentation,
and gastrulation. The mechanisms that regulate them are complex and
involve many different factors operating spatially and temporally
over several days to modulate embryonic chromatin structure, impose
cellular polarity, and direct distinct gene expression programs in
the first cell lineages.
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