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Bioreactor Modeling - Interactions between Hydrodynamics and Biology (Hardcover)
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Bioreactor Modeling - Interactions between Hydrodynamics and Biology (Hardcover)
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Dynamic simulation of bioreactors is a challenge for both the
industrial and academic worlds. Beyond the large number of physical
and biological phenomena to be considered and the wide range of
scales involved, the central difficulty lies in the need to account
for the dynamic behavior of suspended microorganisms. In the case
of chemical reactors, knowledge of the thermodynamic equilibrium
laws at the interfaces makes it possible to produce macroscopic
models by integrating local laws. Microorganisms, on the other
hand, have the ability to modulate the rate of substrate
assimilation. Moreover, the nature of the biochemical
transformations results from a compromise between the needs of the
cell and the available resources. This book revisits the modeling
of bioreactors using a multi-scale approach. It addresses issues
related to mixing, phase-to-phase transfers and the adaptation of
microorganisms to variations in concentration, and explores the use
of population balances for the simulation of bioreactors. By
adopting a multidisciplinary perspective that draws on process
engineering, fluid mechanics and microbiology, this book sheds new
light on the particularity of bioprocesses in relation to physical
and chemical phenomena.
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