Single-Arm Phase II Survival Trial Design provides a comprehensive
summary to the most commonly- used methods for single-arm phase II
trial design with time-to-event endpoints. Single-arm phase II
trials are a key component for successfully developing advanced
cancer drugs and treatments, particular for target therapy and
immunotherapy in which time-to-event endpoints are often the
primary endpoints. Most test statistics for single-arm phase II
trial design with time-to-event endpoints are not available in
commercial software. Key Features: Covers the most frequently used
methods for single-arm phase II trial design with time-to-event
endpoints in a comprehensive fashion. Provides new material on
phase II immunotherapy trial design and phase II trial design with
TTP ratio endpoint. Illustrates trial designs by real clinical
trial examples Includes R code for all methods proposed in the
book, enabling straightforward sample size calculation.
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