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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Regulation of Cancer Immune Checkpoints - Molecular and Cellular Mechanisms and Therapy (Hardcover, 1st ed. 2020)
Loot Price: R5,715
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Regulation of Cancer Immune Checkpoints - Molecular and Cellular Mechanisms and Therapy (Hardcover, 1st ed. 2020)
Series: Advances in Experimental Medicine and Biology, 1248
Expected to ship within 10 - 15 working days
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This book systematically reviews the most important findings on
cancer immune checkpoints, sharing essential insights into this
rapidly evolving yet largely unexplored research topic. The past
decade has seen major advances in cancer immune checkpoint therapy,
which has demonstrated impressive clinical benefits. The family of
checkpoints for mediating cancer immune evasion now includes
CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA
(PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others.
Despite these strides, most patients do not show lasting remission,
and some cancers have been completely resistant to the therapy. The
potentially lethal adverse effects of checkpoint blockade represent
another major challenge, the mechanisms of which remain poorly
understood. Compared to the cancer signaling pathways, such as p53
and Ras, mechanistic studies on immune checkpoint pathways are
still in their infancy. To improve the responses to checkpoint
blockade therapy and limit the adverse effects, it is essential to
understand the molecular regulation of checkpoint molecules in both
malignant and healthy cells/tissues. This book begins with an
introduction to immune checkpoint therapy and its challenges, and
subsequently describes the regulation of checkpoints at different
levels. In closing, it discusses recent therapeutic developments
based on mechanistic findings, and outlines goals for future
translational studies. The book offers a valuable resource for
researchers in the cancer immunotherapy field, helping to form a
roadmap for checkpoint regulation and develop safer and more
effective immunotherapies.
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