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Handbook of Ion Channels (Paperback)
Loot Price: R2,183
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Handbook of Ion Channels (Paperback)
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The New Benchmark for Understanding the Latest Developments of Ion
Channels Ion channels control the electrical properties of neurons
and cardiac cells, mediate the detection and response to sensory
stimuli, and regulate the response to physical stimuli. They can
often interact with the cellular environment due to their location
at the surface of cells. In nonexcitable tissues, they also help
regulate basic salt balance critical for homeostasis. All of these
features make ion channels important targets for pharmaceuticals.
Handbook of Ion Channels illustrates the fundamental importance of
these membrane proteins to human health and disease. Renowned
researchers from around the world introduce the technical aspects
of ion channel research, provide a modern guide to the properties
of major ion channels, and present powerful methods for modeling
ion channel diseases and performing clinical trials for ion channel
drugs. Conveniently divided into five parts, the handbook first
describes the basic concepts of permeation and gating mechanisms,
balancing classic theories and the latest developments. The second
part covers the principles and practical issues of both traditional
and new ion channel techniques and their applications to channel
research. The third part organizes the material to follow the
superfamilies of ion channels. This part focuses on the
classification, properties, gating mechanisms, function, and
pharmacology of established and novel channel types. The fourth
part addresses ion channel regulation as well as trafficking and
distribution. The final part examines several ion channel-related
diseases, discussing genetics, mechanisms, and pharmaceutical
advances.
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