Understanding the role of hedgehog signaling in cancer is
critically important for novel cancer therapeutics. The hedgehog
pathway is a major pathway regulating cell differentiation, tissue
polarity, stem cell maintenance and cell proliferation. It is known
by now that activation of this pathway occurs in a variety of human
cancer, including basal cell carcinomas (BCCs), medulloblastomas,
leukemia, gastrointestinal, lung, ovarian, breast and prostate
cancers. This book provides insightful views suitable for graduate
students, medical students, undergraduate students, basic and
clinical scientists, cancer patients as well as the general
public.
General
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