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Books > Science & Mathematics > Science: general issues > Industrial applications of scientific research & technological innovation
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Pharmaceutical Process Development - Current Chemical and Engineering Challenges (Hardcover)
Loot Price: R4,320
Discovery Miles 43 200
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Pharmaceutical Process Development - Current Chemical and Engineering Challenges (Hardcover)
Series: Drug Discovery, Volume 9
Expected to ship within 12 - 19 working days
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Pharmaceutical process research and development is an exacting,
multidisciplinary effort but a somewhat neglected discipline in the
chemical curriculum. This book presents an overview of the many
facets of process development and how recent advances in synthetic
organic chemistry, process technology and chemical engineering have
impacted on the manufacture of pharmaceuticals. In 15 concise
chapters the book covers such diverse subjects as route selection
and economics, the interface with medicinal chemistry, the impact
of green chemistry, safety, the crucial role of physical organic
measurements in gaining a deeper understanding of chemical
behaviour, the role of the analyst, new tools and innovations in
reactor design, purification and separation, solid state chemistry
and its role in formulation. The book ends with an assessment of
future trends and challenges. The book provides a valuable overview
of: both early and late stage chemical development, how safe and
scaleable synthetic routes are designed, selected and developed,
the importance of the chemical engineering, analytical and
manufacturing interfaces, the key enabling technologies, including
catalysis and biocatalysis, the importance of the green chemical
perspective and solid form issues. The book, written and edited by
experts in the field, is a contemporary, holistic treatise, with a
logical sequence for process development and mini-case histories
within the chapters to bring alive different aspects of the
process. It is completely pharmaceutical themed, encompassing all
essential aspects, from route and reagent selection to manufacture
of the active compound. The book is aimed at both graduates and
postgraduates interested in a career in the pharmaceutical
industry. It informs them about the breadth of the work carried out
in chemical research and development departments, and gives them a
feel for the challenges involved in the job. The book is also of
value to academics who often understand the drug discovery arena,
but have far less appreciation of the drug development area, and
are thus unable to advise their students about the relative merits
of careers in chemical development versus discovery.
General
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