Since the last major compendium dedicated to cyclic nucleotide
phosphodiesterases (PDEs) was published over 15 years ago, an
enormous amount of progress has occurred in the field. There is
great need for a centralized source for key information in this
burgeoning and therapeutically important area of medical research.
Cyclic Nucleotide Phosphodiesterases in Health and Disease
provides an integrated volume covering PDE biology from genes to
organisms. It examines phosphodiesterases as pharmacological
targets as well as the development of specific PDE inhibitors as
therapeutic agents. With contributions from pioneers in the field,
individual chapters describe one of the 11 known mammalian PDE
families including the molecular characteristics, structure,
function, and traits unique to each. Characteristics of PDEs from
lower organisms are also the subject of other chapters since they
provide key insights into PDE functions and are also
pharmacological targets for treatment of a variety of diseases in
humans and domestic animals. Chapters on the current biomedical and
therapeutic research on PDEs include studies on gene-targeted
knockout strategies and compartmentation in cyclic nucleotide
signaling. By unraveling the unique cellular roles for different
PDEs, scientists are beginning to open the door to the therapeutic
use of PDE inhibitors for the treatment of a number of pathological
conditions including asthma and inflammation, pulmonary
hypertension, erectile dysfunction, and stroke.
By collating current information into a coherent and coordinated
perspective, Cyclic Nucleotide Phosphodiesterases in Health and
Disease provides an invaluable reference for industry and
clinicalscientists and points toward future directions of research
and therapeutic advancements in developing selective inhibitors for
these various enzymes.
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