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High-Risk Breast Cancer - Diagnosis (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R2,906
Discovery Miles 29 060
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High-Risk Breast Cancer - Diagnosis (Paperback, Softcover reprint of the original 1st ed. 1989)
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The most meaningful reward to clinicians and researchers is the
absence of recurrent malignancy in their patients. While in some
patients the disease will be cured by resection alone, in other
similarly staged cases the disease will recur despite adequate loco
regional and systemic therapies. Hence, risk assessment is a
complex issue with many related or unrelated prognostic factors
determining outcome. The purpose of this volume is to review some
of the most relevant prognostic factors of newly diagnosed breast
cancer, focusing on fea tures determining the magnitude of risk.
The ultimate value of establishing the significance of each
prognostic factor in a given patient will be the resulting ability
to plan individu alized therapies for patients at different risk of
recurrence at the time of diagnosis. To secure the maximum benefit
for high-risk patients, while avoiding undue toxicity in those with
low-risk lesions, a well-integrated analysis of all known
prognostic factors will be essential in the early postdiagnos tic
period. In addition to well-established staging criteria such as
axillary nodes, tumor size, receptors, scanning and radiographic
examinations, the more sophisticated labora tory techniques, as
discussed by several authors herein, will playa crucial role in
risk assessment. Most of them, - ploidy determination, oncogenes,
tumor markers, monoclonal anti bodies, growth factors, etc. -are
presently available in only a minority of treatment centers.
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