Sixteen years is a long time, not only in human life but also in
the rapid history of contemporary endocrinology. Since the
publication of the first edition of this monograph, numerous new
lines of research and discoveries have greatly contrib- uted to our
knowledge of the physiological and pathological regulation of
aldos- terone biosynthesis in man and animals. The first reports
about a sensitive ra- dioimmunoassay for plasma aldosterone and
about a preparation of dispersed zona glomerulosa cells were
published in 1970 (Mayes et al. 1970; Haning et al. 1970). These
two developments alone turned out to have a tremendous impact on
research in aldosterone physiology (for reviews see Coghlan et al.
1979b; J. F. Tait et al. 1980b). In 1971, atrial natriuretic
peptides, somatostatin, and the precursor molecule of ACTH had not
yet been discovered. Angiotensin antagonists and con-
verting-enzyme inhibitors were not yet available. The clinical
syndrome of hypo- reninemic hypo aldosteronism was unknown. The
possible roles of prostaglandins and dopamine in the control of
aldosterone pwduction had not been considered. Cyclic AMP was then
the only substance with a clearly established second-mes- senger
function.
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