The first and still the only book of its kind, this volume
offers a concise introduction to human genetic linkage analysis and
gene mapping. Jurg Ott provides mathematical and statistical
foundations of linkage analysis for researchers and practitioners,
as well as practical comments on available computer programs and
websites. Each chapter ends with a set of problems, whose solutions
are found at the end of the book.
New to this edition is a chapter on complex traits, such as
diabetes, some cancers, and psychiatric conditions. Also new is an
overview of nonparametric approaches to linkage and association
analysis. A chapter on two-locus inheritance introduces the reader
to many of the intricate aspects of complex traits. Although the
book's primary audience is in the field of genetics, physicians and
others without sophisticated training in genetics can understand
and apply the principles and techniques discussed.
General
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