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Books > Professional & Technical > Biochemical engineering > Biotechnology
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Nuclear Reprogramming and Stem Cells (Paperback, 2012 ed.)
Loot Price: R4,244
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Nuclear Reprogramming and Stem Cells (Paperback, 2012 ed.)
Series: Stem Cell Biology and Regenerative Medicine
Expected to ship within 10 - 15 working days
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Research into the field of stem cell biology has developed
exponentially over recent years, and is beginning to offer
significant promise for unravelling the molecular basis of a
multitude of disease states. Importantly, in addition to offering
the opportunity to delve deeply into the mechanisms that drive
disease aetiology the research is realistically opening the doors
for development of targeted and personalized therapeutic
applications that many considered, until recently, to be nothing
more that a far fetched dream. This volume provides a timely
glimpse into the methods that have been developed to instigate, and
the mechanisms that have been identified to drive, the process of
nuclear reprogramming, chronicling how the field has developed over
the last 50-60 years. Since the early 1950s a small number of
notable experiments have provided significant impetus to the field,
primarily the demonstration of reprogramming ability, first by the
complex cytoplasmic milieu that constitutes the amphibian egg, then
that of the mammalian egg, and finally that of the mammalian
embryonic stem cell. Most recently, the demonstration that a
limited pool of defined molecules is capable of reprogramming a
multitude of cell types has provided massive impetus and
facilitated transition towards realistic therapeutic application.
We have therefore reproduced some of the key articles that
elegantly document these dramatic stages of development of the
field in an inclusive appendix to the book, for the benefit of
readers keen to investigate the history of how the field of stem
cell biology has evolved. Owing to the ever broadening nature of
this field, and the incredible rate at which it is evolving, the
main content of this volume focuses on areas that have shown
significant movement in recent years, are most likely to translate
into personalized therapeutic application, and thus provide
greatest potential for significant impact on human health in the
not too distant future. We recognize that research into many other
disease states and cell types are all equally worthy of discussion.
We would therefore like to acknowledge those researchers involved
whose work we have not been able to include in this volume. Nuclear
Reprogramming and Stem Cells will serve as a valuable resource for
all researchers in the field of stem cell biology, including those
just setting out on their career path as well as those already
established in the field.
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