Peptides in Oncology II - Somatostatin Analogues and Bombesin Antagonists (Paperback, Softcover reprint of the original 1st ed. 1993)

Controlled and predictable interference with hormonal feed- back mechanisms has become a major direction of preclinical and clinical research. There is a steadily increasing number of hormonal pep tides detected and characterized that are re- sponsible for endo-, para-, and autocrine cellular actions. Naturally, these peptides have been studied with regard to their cell growth stimulatory action and, in parallel, the re- spective antagonists are being investigated in terms of their antiproliferative (antineoplastic) function. Among the numerous pep tides of interest in this respect, somatostatin (somatotropin release inhibitory factor) and bombesin antagonizing factors have been the topic of inten- sive research during recent years. No presentation of the role of pep tides in oncology would be complete without a compre- hensive treatise of their physiological, preclinical and clinical functions in the context of their antineoplastic mechanism of action. Somatostatin and its various short- and long-acting analogs have the unique feature of suppressing and inhibiting a wide range of cellular processes including cell proliferation. Recep- tors for these peptides, which belong in a wider sense to the family of neuropeptides or neurotransmitters, are widely dis- tributed, a feature which is not in keeping with the general view of a growth hormone regulatory system. Thus, these substances are found in the gut in a variety of endocrine and exocrine glands including breast, pancreas, and prostate, and in the nervous system.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Recent Results in Cancer Research, 129
Release date:	2012
First published:	1993
Editors:	K. Hoeffken
Dimensions:	235 x 155 x 8mm (L x W x T)
Format:	Paperback
Pages:	136
Edition:	Softcover reprint of the original 1st ed. 1993
ISBN-13:	978-3-642-84958-9
Categories:	Books > Medicine > Surgery > General surgery Books > Medicine > Surgery > Cardiothoracic surgery Books > Medicine > Clinical & internal medicine > Gynaecology & obstetrics > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Promotions
LSN:	3-642-84958-X
Barcode:	9783642849589

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