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Crossover Designs - Testing, Estimation and Sample Size (Hardcover)
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Crossover Designs - Testing, Estimation and Sample Size (Hardcover)
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A comprehensive and practical resource for analyses of crossover
designs For ethical reasons, it is vital to keep the number of
patients in a clinical trial as low as possible. As evidenced by
extensive research publications, crossover design can be a useful
and powerful tool to reduce the number of patients needed for a
parallel group design in studying treatments for non-curable
chronic diseases. This book introduces commonly-used and
well-established statistical tests and estimators in epidemiology
that can easily be applied to hypothesis testing and estimation of
the relative treatment effect for various types of data scale in
crossover designs. Models with distribution-free random effects are
assumed and hence most approaches considered here are
semi-parametric. The book provides clinicians and biostatisticians
with the exact test procedures and exact interval estimators, which
are applicable even when the number of patients in a crossover
trial is small. Systematic discussion on sample size determination
is also included, which will be a valuable resource for researchers
involved in crossover trial design. Key features: * Provides exact
test procedures and interval estimators, which are especially of
use in small-sample cases. * Presents most test procedures and
interval estimators in closed-forms, enabling readers to calculate
them by use of a pocket calculator or commonly-used statistical
packages. * Each chapter is self-contained, allowing the book to be
used a reference resource. * Uses real-life examples to illustrate
the practical use of test procedures and estimators * Provides
extensive exercises to help readers appreciate the underlying
theory, learn other relevant test procedures and understand how to
calculate the required sample size. Crossover Designs: Testing,
Estimation and Sample Size will be a useful resource for
researchers from biostatistics, as well as pharmaceutical and
clinical sciences. It can also be used as a textbook or reference
for graduate students studying clinical experiments.
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