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Crossing the Boundaries of Life - Gunter Blobel and the Origins of Molecular Cell Biology (Paperback)
Loot Price: R893
Discovery Miles 8 930
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Crossing the Boundaries of Life - Gunter Blobel and the Origins of Molecular Cell Biology (Paperback)
Series: Convening Science: Discovery at the Marine Biological Laboratory
Expected to ship within 9 - 15 working days
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A close look at Gunter Blobel's transformative contributions to
molecular cell biology. The difficulty of reconciling chemical
mechanisms with the functions of whole living systems has plagued
biologists since the development of cell theory in the nineteenth
century. As Karl S. Matlin argues in Crossing the Boundaries of
Life, it is no coincidence that this longstanding knot of
scientific inquiry was loosened most meaningfully by the work of a
cell biologist, the Nobel laureate Gunter Blobel. In 1975, using an
experimental setup that did not contain any cells at all, Blobel
was able to target newly made proteins to cell membrane vesicles,
enabling him to theorize how proteins in the cell distribute
spatially, an idea he called the signal hypothesis. Over the next
twenty years, Blobel and other scientists were able to dissect this
mechanism into its precise molecular details. For elaborating his
signal concept into a process he termed membrane topogenesis-the
idea that each protein in the cell is synthesized with an "address"
that directs the protein to its correct destination within the
cell-Blobel was awarded the Nobel Prize in Physiology or Medicine
in 1999. Matlin argues that Blobel's investigative strategy and its
subsequent application addressed a fundamental unresolved dilemma
that had bedeviled biology from its very beginning-the relationship
between structure and function-allowing biology to achieve
mechanistic molecular explanations of biological phenomena.
Crossing the Boundaries of Life thus uses Blobel's research and
life story to shed light on the importance of cell biology for
twentieth-century science, illustrating how it propelled the
development of adjacent disciplines like biochemistry and molecular
biology.
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