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Comparative Effectiveness in Surgical Oncology - Key Questions and How to Answer Them (Hardcover, 2015 ed.)
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Comparative Effectiveness in Surgical Oncology - Key Questions and How to Answer Them (Hardcover, 2015 ed.)
Series: Cancer Treatment and Research, 164
Expected to ship within 12 - 17 working days
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Despite tremendous recent advances in the treatment of most
malignancies, there remain several critical questions for each
cancer. This particularly true for the surgical management of
solid-organ malignancies. Comparative effectiveness is a relatively
new term which encompasses the age-old concepts of how best to
treat cancer patients. Comparative effectiveness is defined as the
direct comparison of healthcare interventions to determine which
work best for which patients when considering the benefits and
risks. The Institute of Medicine has defined comparative
effectiveness research(CER) as the generation and synthesis of
evidence that compares the benefits and harms of alternative
methods to prevent, diagnose, treat, and monitor a clinical
condition or to improve the delivery of care. CER is certainly best
done with well-conducted randomized controlled trials.
Unfortunately, clinical trials are not always feasible owing to the
impracticality of conducting the trial, the considerable cost, and
the time required to complete the trial. These challenges are even
more pronounced with respect to surgical treatment. Thus
alternative approaches may need to be considered in order to
address pressing questions in the care of the oncology patient.
These approaches may include well-conducted retrospective cohort
studies from cancer registries and other data sources, decision and
cost-effectiveness analyses, and other novel methodologies. This
book lays out the current critical questions for each major
malignancy and proposes approaches to gain answers to these
pressing questions.
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