Transgenic plants present enormous potential to become one of
the most cost-effective and safe systems for large-scale production
of proteins for industrial, pharmaceutical, veterinary, and
agricultural uses. Over the past decade, much progress has been
made with respect to the development of vaccines, antibodies, and
other therapeutic proteins. Biopharmaceuticals in Plants: Toward
the Next Century of Medicine provides a comprehensive survey of all
major aspects of the development and production of plant-made
biopharmaceuticals.
Accompanied by an exhaustive list of references to facilitate
further study, this critical volume:
- Describes the theory and practice of modern plant
transformation techniques with respect to nuclear and plastic
genomes
- Outlines the steps involved in the generation of transgenic
plants
- Discusses the engineering of plant virus expression vectors for
transient expression of vaccine proteins and other therapeutics in
plant tissue
- Addresses the significant role of glycosylation in the
production of plant-made mammalian proteins
- Investigates the basis of mucosal immunity using plant-based
oral vaccines
- Examines the scale-up of plant-derived vaccine and therapeutic
proteins in entire crops or in large batch cell suspension
cultures
- Explores the development of clinical trials utilizing
plant-derived biopharmaceutical proteins
- Evaluates risks and biosafety concerns regarding plant-derived
pharmaceuticals
The book concludes with a discussion of the future of
plant-based vaccines and other therapeutic proteins with respect to
commercial viability and as a tool to improve global public health.
Far-reaching in its scope, this text is a baseline reference that
students and researchers in a broad range of fields such as
medicine, plant science, biotechnology, crop science, natural
products chemistry, and engineering will consult regularly. It will
also serve as a useful tool for individuals and companies seeking
to invest in this dynamic area.
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