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Biological Membranes - A Molecular Perspective from Computation and Experiment (Paperback, Softcover reprint of the original 1st ed. 1996)
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Biological Membranes - A Molecular Perspective from Computation and Experiment (Paperback, Softcover reprint of the original 1st ed. 1996)
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The interface between a living cell and the surrounding world plays
a critical role in numerous complex biological processes. Sperm/egg
fusion, virus/cell fusion, exocytosis, endocytosis, and ion
permeation are a few examples of processes involving membranes. In
recent years, powerful tools such as X-ray crystal lography,
electron microscopy, nuclear magnetic resonance, and infra-red and
Raman spectroscopy have been developed to characterize the
structure and dy namics of biomembranes. Despite this progress,
many of the factors responsible for the function of biomembranes
are still not well understood. The membrane is a very complicated
supramolecular liquid-crystalline structure that is largely
composed of lipids, forming a bilayer, to which proteins and other
biomolecules are anchored. Often, the lipid bilayer environment is
pictured as a hydropho bic structureless slab providing a
thermodynamic driving force to partition the amino acids of a
membrane protein according to their solubility. However, much of
the molecular complexity of the phospholipid bilayer environment is
ignored in such a simplified view. It is likely that the atomic
details of the polar head group region and the transition from the
bulk water to the hydrophobic core of the membrane are important.
An understanding of the factors responsible for the function of
biomembranes thus requires a better characterization at the molec
ular level of how proteins interact with lipid molecules, of how
lipids affect protein structure and of how lipid molecules might
regulate protein function.
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