Development of In-Tether Carbon Chiral Center-Induced Helical Peptide - Methodology and Applications (Paperback, 1st ed. 2021)

This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely "chiral center induced peptide helicity (CIH)". The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers' understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.

General

Imprint:	Springer Verlag, Singapore
Country of origin:	Singapore
Series:	Springer Theses
Release date:	2022
First published:	2021
Authors:	Kuan Hu
Dimensions:	235 x 155mm (L x W)
Format:	Paperback
Pages:	102
Edition:	1st ed. 2021
ISBN-13:	978-981-3366-15-2
Categories:	Books > Professional & Technical > Biochemical engineering > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Professional & Technical > Mechanical engineering & materials > Materials science > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	981-3366-15-X
Barcode:	9789813366152

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