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Books > Professional & Technical > Biochemical engineering
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Development of In-Tether Carbon Chiral Center-Induced Helical Peptide - Methodology and Applications (Paperback, 1st ed. 2021)
Loot Price: R4,897
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Development of In-Tether Carbon Chiral Center-Induced Helical Peptide - Methodology and Applications (Paperback, 1st ed. 2021)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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Total price: R4,917
Discovery Miles: 49 170
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This book focuses on the development of stapled peptides, a novel
molecular modality used to regulate aberrant intracellular
protein-protein interactions (PPIs). The author designs and
presents a novel helical peptide stabilization methodology by
constructing a chiral cross-linker moiety, namely "chiral center
induced peptide helicity (CIH)". The book demonstrates that a
precisely positioned carbon chiral center on tether can decisively
determine the secondary structure of a peptide, and that the
R-configured peptide is helical, while the S-configured peptide is
non-helical. Further, it reports that helicity-enhanced R isomer
peptides displayed significantly enhanced cell permeability and
target binding affinity, as well as tumor inhibition efficiency, in
comparison to S isomer peptides. The book will not only advance
readers' understanding of the basic principle of stapled peptides,
but also accelerate the clinical transformation of stapled peptide
drugs.
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