Biomolecular sequence comparison is the origin of
bioinformatics. This book gives a complete in-depth treatment of
the study of sequence comparison.
A comprehensive introduction is followed by a focus on alignment
algorithms and techniques, proceeded by a discussion of the theory.
The book examines alignment methods and techniques, features a new
issue of sequence comparison - the spaced seed technique, addresses
several new flexible strategies for coping with various scoring
schemes, and covers the theory on the significance of high-scoring
segment pairs between two unalignment sequences. Useful appendices
on basic concepts in molecular biology, primer in statistics and
software for sequence alignment are included in this
reader-friendly text, as well as chapter-ending exercise and
research questions
A state-of-the-art study of sequence alignment and homology
search, this is an ideal reference for advanced students studying
bioinformatics and will appeal to biologists who wish to know how
to use homology search tools.
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