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Genomic Elements in Health, Disease and Evolution - Junk DNA (Hardcover, 1st ed. 2015)
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Genomic Elements in Health, Disease and Evolution - Junk DNA (Hardcover, 1st ed. 2015)
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Over 98% of the human genome contains non-coding DNA sequences. For
many years molecular biologists referred to this component of the
genome as the "junk" DNA since it does not code for any "useful"
protein product. Over the last years this notion changed
significantly as scientists discovered that a large part of this
DNA contains various genomic elements that have important roles in
cell physiology. Genomic elements such as non-coding RNAs,
transposons, splicing RNAs, DNA repeats and others were shown to
play a significant role in regulating gene expression. In addition,
all these elements were implicated to contribute in the
pathogenesis or progression of various human diseases. In this
book, the editor will attempt to describe all these genomic
elements that constitute the junk DNA of the genome. For every
genomic element, the physiologic role in the organism, its role in
evolution and any possible involvement in human diseases will be
discussed. Additionally, interaction between these elements in
normal or pathologic condition will be discussed. Since a large
amount of new knowledge is generated daily in regards to these
genomic elements, this book will attempt to combine all the
information in a single publication that can serve as a reference
for future studies. The first part will discuss RNA elements such
as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The
second part of the book will deal with transposons,
retrotransposons and DNA transposons. Finally the third part of the
book will discuss DNA elements that include DNA repeats, conserved
non-coding sequences, distal genomic elements, introns,
pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a
separate chapter will be dedicated to their role in human diseases
since an extensive amount of information exists about these two
elements.
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