In spite of the development of various anticancer drugs, the
therapy of cancer has remained challenging for decades. The current
therapy of cancer is overwhelmed because of the inability to
deliver therapeutics to all regions of a tumor in effective
therapeutic concentrations, intrinsic or acquired resistance to the
treatment with currently available agents via genetic and
epigenetic mechanisms, and toxicity. As a result, cancer therapy
using conventional therapeutics and different types of treatment
regimens using this therapeutics has not led to a convincing
survival benefit of the patients. In this context, Macromolecular
therapeutics offer several advantages over conventional low
molecular therapeutics by various ways such as, enable the use of
larger doses of these agents by limiting the toxicity, by enhanced
permeability and retention into tumors, by tumor targeting using
tumor-specific antibodies, by specific inhibition of oncogenes
using anticancer oligonucleotides etc. Cancer treatment using this
macromolecular therapeutics has considerably improved the survival
benefit for patients. As a result, various macromolecular
therapeutics are already commercialized or are under clinical
development. Although we are far from a real magic bullet today,
looking at the pace of research and current success in this field
of macromolecular therapeutics, it appears that we are approaching
a magic bullet for the efficient treatment of cancer. Thus, we
believe that the subject of this book is very timely, and that the
book will fill an unmet need in the market.
This book is unique and assembles various types and aspects of
macromolecular anticancer therapeutics for cancer therapy in one
shell and conveys the importance of this interdisciplinary field to
the broad audience. Thus, in a nutshell, this book details the
basics of cancer, and various therapeutic strategies such as those
based on macromolecular therapeutics hence can become an important
reference for practitioners, oncologists, medical pharmacologists,
medicinal chemists, biomedical scientists, experimental
pharmacologists, pharmaceutical technologists, and particularly it
can essentially become a handbook of macromolecular therapeutics
for cancer therapy for graduates, post-graduates and Ph.D. students
in these fields.
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