This monograph contains a description of the discovery and
development of a antisecretory therapy in the treatment of
acid-related diseases: omeprazole, the first proton pump inhibitor.
Overviews compare this and other proton pump inhibitors and discuss
their pharmacology, including the mechanism of action, the effect
on Helicobacter pylori infection, and the consequences of profound
inhibition of gastric acid secretion. The pharmaceutic delivery
system is described since it constitutes a special problem with
this class of drugs. The clinical experience with proton pump
inhibitors in acid-related diseases is reviewed with focus on
gastro-esophageal reflux disease and peptic ulcer diseases
including Helicobacter pylori and NSAID-induced ulcerations and
Zollinger-Ellison syndrome. Finally, an overview is presented on
the socio-economic impact of proton pump inhibitors in acid-related
diseases emphasizing the important aspect of quality of life. The
monograph is aimed at a broad readership with an interest in the
development problems of this, at present, most commercially
successful drug; the pharmacology of a "tailor-made" drug for a
specific target; the therapeutic strategies in acid-related
diseases; and the dramatic changes in the long-term outcome results
of the treatment of peptic ulcer diseases where most patients now
can be cured from the disease after only one week of drug therapy.
General
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