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Environmental Cns Stimulation In Aging, Health And Disease (Hardcover)
Loot Price: R3,541
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Environmental Cns Stimulation In Aging, Health And Disease (Hardcover)
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Social and environmental factors have profound impacts on health
and diseases across the lifespan. Each year, hundreds of millions
of animals are used in biomedical research. Yet many experimental
studies utilize animals housed in standard conditions conferring
minimal physical, social, and mental stimulation. Lacking
appreciation of macroenvironment impacts on physiology and disease
risks of the laboratory animals may not only hinder the use of
appropriate animal models for human diseases, but also question the
validity of preclinical assessments of therapeutic agents.This book
summarizes our work on environmental enrichment, a housing
condition for laboratory animals, recapitulating an active
lifestyle by providing a complex physical, social, and cognitive
stimulations. Environmental enrichment exerts a wide range of
benefits on energy balance, cancer, immunity, stress, behavior, and
healthy aging. One underlying mechanism is the activation of a
specific neuroendocrine brain-adipocyte axis with brain-derived
neurotrophic factor as the key brain mediator. This book integrates
recent discoveries regarding mechanisms, mediators, and biomarkers
of environmental enrichment, and discusses its translational
potential.By providing a timely review and discussion of murine
models, this book should be of interest to basic, translational,
and clinical researchers, as well as psychologists, nutrition
scientists, and students that have interest in cancer, obesity,
aging, and genetic disorders.
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