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Advances in Medicine and Biology - Volume 130 (Hardcover)
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Advances in Medicine and Biology - Volume 130 (Hardcover)
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Advances in Medicine and Biology. Volume 130 begins by discussing
proton pump inhibitors (patented in 1979) that selectively target
the H,K- ATPase of gastric parietal cells as a reliable therapeutic
regimen for management of acid reflux disease and gastric bleeding.
Around the same time, H. pylori was recognized as the main cause of
peptic ulcer. The following chapter explores how common bile duct
stones can be predicted and investigated. In addition, the
management of proven ductal calculi is discussed in the
preoperative, intraoperative and postoperative stages. The
investigation of ductal stones is partly dependent upon patient
presentation and liver function tests, but also on availability of
imaging modality and surgical experience. Afterwards, the authors
summarize the current knowledge regarding the toxic effects of STZ
on mammalian DNA and chromosomes, putting emphasis on the most
recent findings on this subject. At the chromosome level, STZ
induces chromosomal aberrations (including those ones involving
telomeric sequences), micronuclei and sister chromatid exchanges. A
review of current state of knowledge of atmospheric parameters
pathophysiological mechanisms and its cardiovascular risk effects
is included. Additionally, some medical prevention strategies that
can provide effective protection against the negative health
effects of global climate change are presented. The authors go on
to summarize the morphogenesis, 3D structure, and rearrangement of
the IHBDs, as well as the cellular changes of cholangiocytes during
development and regeneration. Recent advances based on gene
targeting, lineage tracing, and threedimensional (3D) analysis of
the liver tissue have improved our understanding of the IHBDs
morphogenesis and regeneration. The goal of the concluding chapter
is to describe the current educational preparation and scope of
practice of pediatric advance practice providers (APPs) and provide
guidelines with a new practice model as to how to successfully
integrate APPs into the pediatric emergency department. The
pediatric health care and role of an acute care APP has evolved
significantly in the last few years, with APPs seeing patients
ranging from non-urgent to all kinds of pediatric emergencies.
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