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Advances in Medicine and Biology - Volume 134 (Hardcover)
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Advances in Medicine and Biology - Volume 134 (Hardcover)
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The eyes are highly diversified photosensitive structures. In all
vertebrates, eyes resemble in molecular composition and are
predominantly composed of extracellular matrix (ECM). Advances in
Medicine and Biology. Volume 134 explores the dual role of ECM in
ocular homeostasis and diseases and discusses how this duality can
be used to treat such diseases. The view on ECM biology offered by
this work is translational and adress concepts of basic science and
clinical-surgical issues.Following this, the authors aim to provide
information about the mechanisms of oxidative stress-mediated
apoptosis, to provide updates for previous studies update and some
of the current paradigms discussed and to provide a basis for
future studies. This review highlights the elementary value of
apoptosis, including its effect on tissue homeostasis and cellular
stress.The aim of the subsequent study was to investigate
microcirculation peculiarities of the covering tissues of the limbs
and body in patients with orthopedic pathology and in
track-and-field athletes having reached high sport
mastership.Spontaneous cerebrospinal fluid (CSF) leaks are a
clinical entity in which CSF rhinorrhea occurs in the absence of
any inciting event. Spontaneous CSF leaks are associated with
elevated intracranial pressure (ICP) or underlying idiopathic
intracranial hypertension (IIH). The authors report on a cohort of
patients who have undergone nasal endoscopic repair for spontaneous
CSF leaks.Wound healing is a widespread feature of multicellular
organisms. Evidence illustrates that apoptosis has very important
roles in the various phases of the wound healing process. As such,
the authors maintain the importance of keeping up-to-date with
studies on apoptosis and its associated mechanisms highlighted in
the wound healing process, providing a systematic analysis of
recent molecular research in wound healing applications.Despite
enormous improvements in supportive and standard care, septic shock
and liver failure remain major causes of morbidity and mortality in
critically ill patients. Plasma separation via centrifugation is a
common method for therapeutic plasma exchange in patients with
liver failure and septic shock. The authors suggest that the use of
a centrifugal approach rather than regular plasma filtration
enables the transfer of larger particles into the resulting plasma
fraction. The possible advantages of using centrifugation in
comparison to hemofiltration in blood cleaning techniques are
currently hypothetical.The most commonly used staging
classification of the classical form of Kaposis sarcoma was
presented by Brambilla et al. in 2003. The authors distinguished
four stages of the disease based on the morphology of the cutaneous
lesions, location of the skin changes, presence of complications
and internal organ involvement. The clinical presentation,
diagnosis and management of classical Kaposis sarcoma will be
discussed in the closing chapter.
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