Early detection of colorectal cancer is a strategy for reducing
death of the disease. Detection in this book refers to both
clinical diagnosing and to presymptomatic detection of colorectal
neoplasia. Five research projects, different in character are
described. A population-based audit of the diagnostic process
includes work-up times, the use of family history for risk
assessment and the benefit of faecal occult blood test in
symptomatic patients. The next study is an estimation of the
importance of symptom duration in colorectal cancer on prognosis
and it includes a description of symptoms by sublocalisation.
Family history was meticulously mapped out for all colorectal
cancer patients in one county during three years in the next
project and a risk- stratified screening was proposed. Cancer of
the sigmoid was identified as a separate entity. The last two
studies are about faecal DNA and the use of mutations in the APC
gene and microsatellite BAT 26 for detection of colorectal
neoplasia. Results and implications for screening are discussed.
General
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