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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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In Vitro Neurotoxicology - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011)
Loot Price: R4,245
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In Vitro Neurotoxicology - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011)
Series: Methods in Molecular Biology, 758
Expected to ship within 10 - 15 working days
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In recent years, the need to develop acceptable alternatives to
conventional animal testing for neurotoxicity and developmental
neurotoxicity has been increasingly recognized, and much effort is
being directed toward the development of alternative models,
utilizing mostly mammalian cells in culture but also non-mammalian
model systems. In Vitro Neurotoxicology: Methods and Protocols
presents a series of cellular, biochemical, and molecular
methodological protocols in the area of in vitro neurotoxicology,
with an emphasis on mammalian cell culture systems. Opening with a
section on methodologies for preparing several cellular systems of
variable complexity, amenable for in vitro neurotoxicological
studies, the thorough volume continues with coverage of methods to
measure cellular death and major mechanisms, methods for assessing
mechanisms of nervous system cell toxicity related to impairment of
cell signaling, while a final section illustrates additional
methods for assessing important nervous system processes such as
cell proliferation, neuritogenesis, and synaptogenesis. Written in
the highly successful Methods in Molecular Biology (TM) series
format, chapters include introductions to their respective
subjects, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Comprehensive and
cutting-edge, In Vitro Neurotoxicology: Methods and Protocols
serves researchers with an interest in assessing or characterizing
the potential neurotoxicity of environmental contaminants, drugs,
or other chemicals.
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