This book offers a comprehensive overview of current challenges and
strategies to regenerate load-bearing and calcified human tissues,
including bone, cartilage,tendon, ligaments and dental structures
(dentin, enamel, cementum and periodontal ligament). Tissue
engineering has long held great promises as an improved treatment
option for conditions affecting mineralized and load-bearing
structures in the body. Although significant progress has been
achieved in recent years, a number of challenges still exist.
Scaffold vascularization, new biofabrication methods (3D printing,
lithography, microfabrication), peptide conjugation methods,
interface engineering, scaffold mechanical properties, iPS cells,
organs-on-a-chip, are some of the topics discussed in this book.
More specially, in the first section readers will find an overview
of emerging biofabrication methods. In section 2, applied
strategies for regeneration of (2.1) bone, cartilage and ligament,
as well as (2.2) dentin, cementum, enamel and periodontal ligament
are discussed across 14 chapters. While other volumes have
addressed the regeneration of individual tissues, or exclusively
focused on different regenerative strategies, the focus of this
work is to bring together researchers integrating backgrounds in
materials sciences, engineering, biology, mechanics, fluidics, etc,
to address specific challenges common to regeneration of several
load-bearing and calcified tissues. Therefore, this book provides a
unique platform to stimulate progress in the regeneration of
functional tissue substitutes. We envision that this book will
represent a valuable reference source for university and college
faculties, post-doctoral research fellows, senior graduate
students, and researchers from R&D laboratories in their
endeavors to fabricate biomimetic load bearing tissues.
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