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Stem Cells and Cancer Stem Cells, Volume 11 - Therapeutic Applications in Disease and injury (Hardcover, 2014 ed.)
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Stem Cells and Cancer Stem Cells, Volume 11 - Therapeutic Applications in Disease and injury (Hardcover, 2014 ed.)
Series: Stem Cells and Cancer Stem Cells, 11
Expected to ship within 12 - 17 working days
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Volume 11 in this series discusses therapeutic applications of stem
cells in disease and tissue injury. Coverage includes pluripotent
stem cells, which can give rise to the endodermal, ectodermal, and
mesodermal lineages; multipotent stem cells, which can generate all
cells in a particular lineage and unipotent stem cells, which can
give rise to only one cell type. This volume also examines cancer
stem cells, tumor-initiating cells which possesses the capacity of
self-renewal and can give rise to the heterogeneous lineages of
cancer cells that comprise the tumor. Coverage extends to molecular
mechanisms underlying the derivation and expansion of human
embryonic stem cells, the role of specific proteins in the
maintenance and inhibition of extraembryonic differentiation of
these cells and the role of signaling responsible for the
self-renewal of mouse embryonic stem cells. Nine chapters discuss
the clinical importance of cancer stem cells, encompassing glioma,
leukemia, ovarian cancer, pediatric sarcomas and head and neck
squamous cell carcinoma. The role of cancer stem cells is also
elucidated in epithelial-to-mesenchymal transition in spreading
head and neck squamous cell carcinoma. The book goes on to survey
therapeutic application of stem cells of hematopoietic and
non-hematopoietic origin for regeneration of bones, including in
osteoporotic bone disease; to illuminate the application of
hematopoietic stem cells in bone regeneration and to discuss their
use as a biomarker to facilitate determination of a treatment. The
contributors review cells as biomarkers for pediatric solid tumors,
and weigh the advantages and limitations of hematopoietic stem cell
transplantation. Also included are details of neural stem cell
engraftment in the injured spinal cord; the regenerative potential
of neural stem/progenitor cells of newborns and cancer gene therapy
potential using neural stem cells. Like the preceding volumes in
the series, this book is distinguished for its comprehensive
approach, its distinguished roster of 58 contributors representing
10 different countries and its thorough review of leading-edge
technology and methods.
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